論文 / Publication

In press

二橋佑磨, 高谷智英*. 筋芽細胞の分化におけるコレシストキニンの作用. 北信越畜産学会報. in press.


Nohira N, Shinji S, Nakamura S, Nihashi Y, Shimosato T, Takaya T*. Myogenetic oligodeoxynucleotides as anti-nucleolin aptamers inhibit the growth of embryonal rhabdomyosarcoma cells. Biomedicines. 2022; 10: 2691. † equally contributed to the study.

Nihashi Y, Yamamoto M, Shimosato T, Takaya T*. Myogenetic oligodeoxynucleotide restores differentiation and reverses inflammation of myoblasts aggravated by cancer-conditioned medium. Muscles. 2022; 1: 111-120.

Nihashi Y, Miyoshi M, Umezawa K, Shimosato T, Takaya T*. Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner. Nanomaterials. 2022; 12: 1680.

Makida S, Kametani K, Hosotani M, Takahashi N, Iwasaki T, Hasegawa Y, Takaya T, Ueda H, Watanabe T. Three-dimensional structural analysis of mitochondria composing each subtype of fast-twitch muscle fibers in chicken. J Vet Med Sci. 2022; 84: 809-816.

高谷智英*. ロコモ創薬シーズとしての筋・骨形成型オリゴ DNA. Medical Science Digest. 2022; 48: 244-245. 総説.


Nihashi Y, Shinji S, Umezawa K, Shimosato T, Ono T, Kagami H, Takaya T*. Myogenetic oligodeoxynucleotide complexed with berberine promotes differentiation of chicken myoblasts. Anim Sci J. 2021; 92: e13597.

Nakamura S, Yonekura S, Shimosato T, Takaya T*. Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus. Front Physiol. 2021; 12: 679152.

Takaya T*, Nihashi Y, Ono T, Kagami H. Transcription of endogenous retrovirus group K members and their neighboring genes in chicken skeletal muscle myoblasts. J Poult Sci. 2021; 58: 79-87.

Shinji S, Umezawa K, Nihashi Y, Nakamura S, Shimosato T, Takaya T*. Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin. Front Cell Dev Biol. 2021; 8: 616706.

高谷智英*. 核酸医薬品シーズとしての微生物オリゴ DNA. バイオインダストリー. 2021; 38(12): 1-8. 総説.

高谷智英*. 乳酸菌オリゴ DNA による幹細胞の運命制御. 化学と生物. 2021; 59: 284-289. 総説.


Hosotani M, Kawasaki T, Hasegawa Y, Wakasa Y, Hoshino M, Takahashi N, Ueda H, Takaya T, Iwasaki T, Watanabe T. Physiological and pathological mitochondrial clearance is related to pectoralis major muscle pathogenesis in broilers with wooden breast syndrome. Front Physiol. 2020; 11: 579.

Shinji S, Nakamura S, Nihashi Y, Umezawa K, Takaya T*. Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells. Biosci Biotechnol Biochem. 2020; 84: 63-75. † equally contributed to the study.

高谷智英*. 筋萎縮治療薬としての筋形成型オリゴ DNA の開発. アグリバイオ. 2020; 4: 546-547. 総説.


Nihashi Y, Umezawa K, Shinji S, Hamaguchi Y, Kobayashi H, Kono T, Ono T, Kagami H, Takaya T*. Distinct cell proliferation, myogenic differentiation, and gene expression in skeletal muscle myoblasts of layer and broiler chickens. Sci Rep. 2019; 9: 16527.

Nihashi Y, Ono T, Kagami H, Takaya T*. Toll-like receptor ligand-dependent inflammatory responses in chick skeletal muscle myoblasts. Dev Comp Immunol. 2019; 91: 115-122.


Mitani T, Takaya T, Harada N, Katayama S, Yamaji R, Nakamura S, Ashida H. Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes. Arch Biochem Biophys. 2018; 646: 98-106.


Takaya T*, Nihashi Y, Kojima S, Ono T, Kagami H. Autonomous xenogenic cell fusion of murine and chick skeletal muscle myoblasts. Anim Sci J. 2017; 88: 1880-1885.

高谷智英*. 筋疾患における転写因子 GATA4 の役割. 信州大学農学部紀要. 2017; 53: 9-16. 総説.


Takanabe-Mori R, Ono K, Wada H, Takaya T, Ura S, Yamakage H, Satoh-Asahara N, Shimatsu A, Takahashi Y, Fujita M, Fujita Y, Sawamura T, Hasegawa K. Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation of current smokers. J Atheroscler Thromb. 2013; 20: 585-590.

高谷智英, 沢村達也. 心血管機能における LOX-1 の意義とその診断治療への応用. 心血管薬物療法. 2013; 1: 45-50. 総説.


Takaya T, Nishi H, Horie T, Ono K, Hasegawa K. Roles of microRNAs and myocardial cell differentiation. Prog Mol Biol Transl Sci. 2012; 111: 139-152. Review.

Satoh-Asahara N, Shimatsu A, Sasaki Y, Nakaoka H, Himeno A, Tochiya M, Kono S, Takaya T, Ono K, Wada H, Suganami T, Hasegawa K, Ogawa Y. Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia. Diabetes Care. 2012; 35: 2631-2639.

善本亮, 西塚太一, 中野厚史, 藤田佳子, 垣野明美, 高谷智英, 沢村達也. プロシアニジンは酸化 LDL と LOX-1 の結合を阻害し, 血管壁脂質沈着を抑制する. 生存科学. 2012; 22: 27-43. 総説.


Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Hasegawa K. Distinct characteristics of circulating vascular endothelial growth factor-A and C levels in human subjects. PLoS One. 2011; 6: e29351.

Yoshimoto R, Fujita Y, Kakino A, Iwamoto S, Takaya T, Sawamura T. The discovery of LOX-1, its ligands and clinical significance. Cardiovasc Drugs Ther. 2011; 25: 379-391. Review.

Sunagawa Y, Morimoto T, Wada H, Takaya T, Katanasaka Y, Kawamura T, Yanagi S, Marui A, Sakata R, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K. A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats. Circ J. 2011; 75: 2151-2159.

Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Watanabe S, Takaya T, Tamaki Y, Takanabe-Mori R, Wada H, Hasegawa K, Iwanaga Y, Kawamura T, Kita T, Kimura T. MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes. Mol Cell Biol. 2011; 31: 744-755.

Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K. Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes. J Cell Physiol. 2011; 226: 248-254.

高谷智英, 長谷川浩二. 心筋細胞分化とマイクロ RNA. 血管医学. 2011; 12: 261-267. 総説.

高谷智英, 岩元真, 垣野明美, 藤田佳子, 中野厚史, 沢村達也. 動脈硬化予防薬としての LOX-1 ブロッカーの探索. 循環器病研究の進歩. 2011; 32: 65-72. 総説.


Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Horie T, Satoh-Asahara N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K. Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice. Biochem Biophys Res Commun. 2010; 398: 576-580.

Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T. Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. Cardiovasc Res. 2010; 88: 314-323.

Takaya T, Wada H, Morimoto T, Sunagawa Y, Kawamura T, Takanabe-Mori R, Shimatsu A, Fujita Y, Sato Y, Fujita M, Kimura T, Sawamura T, Hasegawa K. Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts. Circ J. 2010; 74: 723-729.

Sunagawa Y, Morimoto T, Takaya T, Kaichi S, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K. Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. J Biol Chem. 2010; 285: 9556-9568.

Yoshida Y, Morimoto T, Takaya T, Kawamura T, Sunagawa Y, Wada H, Fujita M, Shimatsu A, Kita T, Hasegawa K. Aldosterone signaling associates with p300/GATA4 transcriptional pathway during the hypertrophic response of cardiomyocytes. Circ J. 2010; 74: 156-162.


Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, Wada H, Kita T, Shimatsu A, Hasegawa K. MicroRNA-1 and microRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells. Circ J. 2009; 73: 1492-1497. Commented in Editorial.


Takanabe R, Ono K, Abe Y, Takaya T, Horie T, Wada H, Kita T, Satoh N, Shimatsu A, Hasegawa K. Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem Biophys Res Commun. 2008; 376: 728-732.

Morimoto T, Fujita M, Kawamura T, Sunagawa Y, Takaya T, Wada H, Shimatsu A, Kita T, Hasegawa K. Myocardial regulation of p300 and p53 by doxorubicin involves ubiquitin pathways. Circ J. 2008; 72: 1506-1511.

Wada H, Abe M, Ono K, Morimoto T, Kawamura T, Takaya T, Satoh N, Fujita M, Kita T, Shimatsu A, Hasegawa K. Statins activate GATA-6 and induce differentiated vascular smooth muscle cells. Biochem Biophys Res Commun. 2008; 374: 731-736.

Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H, Nagasawa A, Komeda M, Fujita M, Shimatsu A, Kita T, Hasegawa K. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest. 2008; 118: 868-878.

Takaya T, Kawamura T, Morimoto T, Ono K, Kita T, Shimatsu A, Hasegawa K. Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes. J Biol Chem. 2008; 283: 9828-9835. Selected as a Paper of the Week.

Adachi R, Takaya T, Kuriyama K, Higashibata A, Ishioka N, Kagawa H. Spaceflight results in increase of thick filament but not thin filament proteins in the paramyosin mutant of Caenorhabditis elegans. Adv Space Res. 2008; 41: 816-823.


Hosseinkhani M, Hasegawa K, Ono K, Kawamura T, Takaya T, Morimoto T, Wada H, Shimatsu A, Prat SG, Suemori H, Nakatsuji N, Kita T. Trichostatin A induces myocardial differentiation of monkey ES cells. Biochem Biophys Res Commun. 2007; 356: 386-391.

Kagawa H, Takaya T, Ruksana R, Anokye-Danso F, Amin MZ, Terami H. C. elegans model for studying tropomyosin and troponin regulations of muscle contraction and animal behavior. Adv Exp Med Biol. 2007; 592: 153-161. Review.

森本達也, 砂川陽一, 川村晃久, 高谷智英, 和田啓道, 宮本昌一, 長澤淳, 米田正始, 藤田正俊, 島津章, 北徹, 長谷川浩二. 心筋細胞核をターゲットとした新しい心不全治療の可能性. 適応医学. 2007; 11: 19-26. 総説.


Ruksana R, Kuroda K, Terami H, Bando T, Kitaoka S, Takaya T, Sakube Y, Kagawa H. Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans. Genes Cells. 2005; 10: 261-276.