| Date |
Presenter |
Article |
| 2025/12/19 |
Akane Fuse |
Yoshimatsu M, Nakamura R, Bing R, Gartling GJ, Branski RC. Smad2/3 signaling mediates the atrophic response in vocal fold myoblasts in vitro. Laryngoscope. 2025; 1-13. |
| 2025/12/12 |
Koyuki Naka |
Cheon YH, Lee CH, Chung CH, Kim JY, Lee MS. Vigeo promotes myotube differentiation and protects dexamethasone-induced skeletal muscle atrophy via regulating the protein degradation, AKT/mTOR, and AMPK/Sirt-1/PGC1α signaling pathway in vitro and in vivo. Nutrients. 2024; 16: 2687. |
| 2025/12/05 |
Yoshihiro Saitoh |
Oles AR, Yu PY, Udeme AA, Sharma S, Londhe P, Pryce BR, Talbert EE, Hill EM, Miranda CJ, Kaspar BK, Arnold MA, Hyland J, London CA, Houghton PJ, Wang DJ, Roberts RD, Guttridge DC. MyoD is essential in rhabdomyosarcoma by promoting survival through differentiation and CYLD. iScience. 2025; 28: 113149. |
| 2025/11/28 |
Chihaya Kimura |
Wu C, Huang Z, Chen J, Li N, Cai Y, Chen J, Ruan G, Han W, Ding C, Lu Y. Efficiently directing differentiation and homing of mesenchymal stem cells to boost cartilage repair in osteoarthritis via a nanoparticle and peptide dual-engineering strategy. Biomaterials. 2025; 312: 122720. |
| 2025/11/21 |
Chika Ishida |
石田智香. 修士論文中間発表会 (予演). |
| Momo Matsushima |
松島もも. 修士論文中間発表会 (予演). |
| 2025/11/14 |
Koyuki Naka |
Kim S, Kim A, Tran MN, Kim SY, Min BD, Kim NS, Park SM. Ginsenoside Rc inhibits TGF-β signaling and downregulates nucleolin to mitigate oxidative stress-induced muscle atrophy. Life Sci. 2025; 382: 124011. |
| 2025/11/06 |
Yoshihiro Saitoh |
Chronopoulos A, Chavez I, Vemula CK, Mittal N, Zamloot V, Pan Y, Han SJ, Park J. The PAX3-FOXO1 fusion gene reduces cell-ECM interactions and TGFβ signaling in rhabdomyosarcoma. J Cell Biol. 2025; 224: e202408155. |
| 2025/10/30 |
Momo Matsushima |
Huang C, Wang Y. Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1. Cell Death Dis. 2022; 13: 919. |
| 2025/10/23 |
Chika Ishida |
Li Y, Li C, Zhang W, Le S, Zhou J, Luo B, Xie P, Yan B. Theaflavin reduces Achilles tendon heterotopic ossification in mice through the TGF-β/Smad signaling pathway. Biochem Pharmacol. 2025; 242: 117387. |
| 2025/10/17 |
Chihaya Kimura |
Fu L, Wu J, Li P, Zheng Y, Zhang Z, Yuan X, Ding Z, Ning C, Sui X, Liu S, Shi S, Guo Q, Lin Y. A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage. Bioact Mater. 2024; 40: 634-648. |
| 2025/10/10 |
Koyuki Naka |
仲こゆき. 研究紹介. |
| 2025/10/03 |
Yoshihiro Saitoh |
斎藤欣洋. 研究紹介. |
| 2025/09/26 |
Chika Ishida |
石田智香. 研究紹介. |
| 2025/09/19 |
Momo Matsushima |
松島もも. 研究紹介. |
| 2025/09/10 |
Chihaya Kimura |
木村智勇. 研究紹介. |
| 2025/09/05 |
Tomohide Takaya |
高谷智英. 研究紹介. |
| 2025/07/24 |
Koyuki Naka |
Huayamares SG, Lokugamage MP, Rab R, Da Silva Sanchez AJ, Kim H, Radmand A, Loughrey D, Lian L, Hou Y, Achyut BR, Ehrhardt A, Hong JS, Sago CD, Paunovska K, Echeverri ES, Vanover D, Santangelo PJ, Sorscher EJ, Dahlman JE. High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo. J Control Release. 2023; 357: 394-403. |
| 2025/07/18 |
Yoshihiro Saitoh |
Kalita B, Martinez-Cebrian G, McEvoy J, Allensworth M, Knight M, Magli A, Perlingeiro RCR, Dyer MA, Stewart E, Dynlacht BD. PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma. Cell. 2025; 188: 2757-2777. |
| 2025/07/04 |
Yoshihiro Saitoh |
斎藤欣洋. 修士院試 (予演). |
| Koyuki Naka |
仲こゆき. 修士院試 (予演). |
| 2025/06/27 |
Chihaya Kimura |
木村智勇, 高谷智英. 骨形成型オリゴ DNA による前駆細胞と間葉系幹細胞の骨・軟骨分化誘導. 日本核酸医薬学会第10回年会 (予演). |
| Chika Ishida |
石田智香, 松島もも, 高谷智英. 抗ヌクレオリンアプタマー iSN04 は BMP2-Smad1/5 シグナル伝達経路を阻害して異所性骨化を抑制する. 日本核酸医薬学会第10回年会 (予演). |
| Momo Matsushima |
松島もも, 石田智香, 高谷智英. 抗ヌクレオリンアプタマー iSN04 は Smad1/5 のリン酸化を阻害して BMP シグナルに干渉する. 日本核酸医薬学会第10回年会 (予演). |
| Yoshihiro Saitoh |
斎藤欣洋, 高谷智英. 横紋筋肉腫細胞に対するビンクリスチンと抗ヌクレオリンアプタマー iSN04 の併用効果. 日本核酸医薬学会第10回年会 (予演). |
| Koyuki Naka |
仲こゆき, 高谷智英. 脂質ナノ粒子化した抗ヌクレオリンアプタマー iSN04 による細胞分化と炎症の制御. 日本核酸医薬学会第10回年会 (予演). |
| 2025/06/13 |
Momo Matsushima |
Xin J, Wang Z, Shen Y, Bai J, Shen Y. S100 calcium‑binding protein A16 suppresses the osteogenic differentiation of rat bone marrow mesenchymal stem cells by inhibiting SMAD family member 4 signaling. Exp Ther Med. 2024; 27: 250. |
| 2025/06/06 |
Chika Ishida |
Coculo L, Wits M, Mariani I, Fianco G, Cappato S, Bocciardi R, Pedemonte N, Volpe E, Ciolfi S, Sessa RL, Rinaldo S, Cutruzzola F, Trisciuoglio D, Goumans MJ, Sanchez-Duffhues G, Stagni V. Interplay between ALK2(R206H) mutant receptor and autophagy signaling regulates receptor stability and its chondrogenic functions. Cell Death Discov. 2025; 11: 117. |
| 2025/05/30 |
Chihaya Kimura |
Xie M, Zhang Y, Xiong Z, Hines S, Shang J, Clark KL, Tan S, Alexander PG, Lin H. Generation of hyaline-like cartilage tissue from human mesenchymal stromal cells within the self-generated extracellular matrix. Acta Biomater. 2022; 149: 150-166. |
| 2025/05/23 |
Tomohide Takaya |
Lessard SJ, MacDonald TL, Pathak P, Han MS, Coffey VG, Edge J, Rivas DA, Hirshman MF, Davis RJ, Goodyear LJ. JNK regulates muscle remodeling via myostatin/SMAD inhibition. Nat Commun. 2018; 9: 3030. |
| 2025/05/16 |
Koyuki Naka |
Segales J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardi M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M, Hee Lee J, Munoz-Canoves P. Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nat Commun. 2020; 11: 189. |
| 2025/05/09 |
Yoshihiro Saitoh |
Sun X, Zhang W, Gou C, Wang X, Wang X, Shao X, Chen X, Chen Z. AS1411 binds to nucleolin via its parallel structure and disrupts the exos-miRNA-27a-mediated reciprocal activation loop between glioma and astrocytes. Biochim Biophys Acta Mol Basis Dis. 2024; 1870: 167211. |
| 2025/05/02 |
Momo Matsushima |
Horie T, Fukasawa K, Yamada T, Mizuno S, Iezaki T, Tokumura K, Iwahashi S, Sakai S, Suzuki A, Kubo T, Osumi R, Tomizawa A, Ochi H, Sato S, Kaneda K, Takahashi S, Hinoi E. Erk5 in bone marrow mesenchymal stem cells regulates bone homeostasis by preventing osteogenesis in adulthood. Stem Cells. 2022: 40: 411-422. |
| 2025/04/25 |
Chika Ishida |
Egerman MA, Zhang Y, Donne R, Xu J, Gadi A, McEwen C, Salmon H, Xiong K, Bai Y, Germino M, Barringer K, Jimenez Y, Del Pilar Molina-Portela M, Shavlakadze T, Glass DJ. ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice. Skelet Muscle. 2025; 15: 4. |
| 2025/04/18 |
Chihaya Kimura |
Zheng S, Zhou H, Chen Z, Li Y, Zhou T, Lian C, Gao B, Su P, Xu C. Type III transforming growth factor-β receptor RNA interference enhances transforming growth factor β3-induced chondrogenesis signaling in human mesenchymal stem cells. Stem Cells Int. 2018; 2018: 4180857. |
| 2025/04/11 |
Tomohide Takaya |
Qiu F, Xie D, Chen H, Wang Z, Huang J, Cao C, Liang Y, Yang X, He DY, Fu X, Lu A, Liang C. Generation of cytotoxic aptamers specifically targeting fibroblast-like synoviocytes by CSCT-SELEX for treatment of rheumatoid arthritis. Ann Rheum Dis. 2024; XX: XXXX. |
| 2025/02/21 |
Koyuki Naka |
Ban Y, Ando Y, Terai Y, Matsumura R, Nakane K, Iwai S, Sato S, Yamamoto J. Profiling of i-motif-binding proteins reveals functional roles of nucleolin in regulation of high-order DNA structures. Nucleic Acids Res. 2024; 52: 13530-13543. |
| 2025/02/14 |
Yoshihiro Saitoh |
Hebron KE, Perkins OL, Kim A, Jian X, Girald-Berlingeri SA, Lei H, Shern JF, Conner EA, Randazzo PA, Yohe ME. ASAP1 and ARF1 regulate myogenic differentiation in rhabdomyosarcoma by modulating TAZ activity. Mol Cancer Res. 2024; XX: XXXX. |
| 2025/01/31 |
Yuri Hirabayashi |
平林ゆり. 抗ヌクレオリンアプタマーの腫瘍細胞増殖抑制作用の検討. 修士論文発表会 (予演). |
| 2025/01/24 |
Chika Ishida |
石田智香. 異所性骨化における筋形成型オリゴ DNA の作用. 専攻研究論文発表会 (予演). |
| Momo Matsushima |
松島もも. BMP2 依存的な骨分化における筋形成型オリゴ DNA の作用. 専攻研究論文発表会 (予演). |
| 2025/01/16 |
Chihaya Kimura |
Kondo M, Kameishi S, Kim K, Metzler NF, Maak TG, Hutchinson DT, Wang AA, Maehara M, Sato M, Grainger DW, Okano T. Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment. NPJ Regen Med. 2021; 6: 65. |
